The best US work visa for Indians depends on qualifications, job role, and employer sponsorship. The H-1B visa is the most popular for professionals in specialty occupations such as IT, engineering, healthcare, and finance. Other suitable options include the L-1 visa for intra-company transfers, O-1 visa for individuals with extraordinary abilities, and H-2B for temporary non-agricultural work. Highly skilled professionals with niche expertise usually benefit from employer-sponsored visas. Choosing the right visa requires aligning skills, experience, and job offers with visa eligibility criteria.